Anti-TLR8/CD288 antibody [103E11.01] (STJ16102364)

SKU:
STJ16102364-100

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Host: Rat
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rat monoclonal antibody anti-TLR8/CD288 is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: 103E11.01
Conjugation: Unconjugated
Isotype: IgG2a
Purification: Affinity Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for up to 1 year.
Gene Symbol: Tlr8
Gene ID: 170744
Uniprot ID: TLR8_MOUSE
Function Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively.
Protein Name Toll-Like Receptor 8
Cd Antigen Cd288
Database Links Reactome: R-MMU-1679131
Cellular Localisation Endosome Membrane
Single-Pass Type I Membrane Protein
Endosomal Localization Confers Distinctive Proteolytic Processing
Alternative Antibody Names Anti-Toll-Like Receptor 8 antibody
Anti-Cd Antigen Cd288 antibody
Anti-Tlr8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance