Anti-TLR7 antibody (ECD) (STJ13102489)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the extracellular domain of human TLR7 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Goat polyclonal anti-TLR7 (ECD) for use in IHC, WB and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB/FC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB, Flow Cyt. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | TLR7 |
| Gene ID | 51284 |
| Uniprot ID | TLR7_HUMAN |
| Immunogen | A synthetic peptide from the extracellular domain of human TLR7 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | ECD |
| Specificity | Specific for TLR7. |
Additional Info
| Function | Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. In plasmacytoid dendritic cells, RNASET2 endonuclease cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state. |
| Protein Name | Toll-Like Receptor 7 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-168181Reactome: R-HSA-5686938Reactome: R-HSA-9679191Reactome: R-HSA-9692916Reactome: R-HSA-9705671Reactome: R-HSA-975110Reactome: R-HSA-975138Reactome: R-HSA-975155Reactome: R-HSA-9824856Reactome: R-HSA-9833110 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinEndosomeLysosomeCytoplasmic VesiclePhagosomeRelocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Stimulation With Agonist |
| Alternative Antibody Names | Anti-Toll-Like Receptor 7 antibodyAnti-TLR7 antibodyAnti-UNQ248 antibodyAnti-PRO285 antibody |
Information sourced from Uniprot.org