Anti-TLR1 antibody (200-250) (STJ503274)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 200-250 on mouse toll-like receptor 1 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-TLR1 (200-250) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.55-0.67 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500ELISA: 1:20, 000IP: 1:200IHC: 1:100ICC: 1:100IF: 1:100 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Tlr1 |
| Gene ID | 21897 |
| Uniprot ID | TLR1_MOUSE |
| Immunogen | Synthetic peptide taken within amino acid region 200-250 on mouse toll-like receptor 1 protein. |
| Immunogen Region | 200-250 |
Additional Info
| Function | Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen. |
| Protein Name | Toll-Like Receptor 1Toll/Interleukin-1 Receptor-Like ProteinTilCd Antigen Cd281 |
| Database Links | Reactome: R-MMU-1461957Reactome: -MMU-5686938 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmic VesiclePhagosome MembraneMembrane RaftGolgi ApparatusDoes Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial LigandIn Response To Triacylated LipoproteinsTlr2:Tlr1 Heterodimers Are Recruited In Lipid RaftsThis Recruitment Determine The Intracellular Targeting To The Golgi Apparatus |
| Alternative Antibody Names | Anti-Toll-Like Receptor 1 antibodyAnti-Toll/Interleukin-1 Receptor-Like Protein antibodyAnti-Til antibodyAnti-Cd Antigen Cd281 antibodyAnti-Tlr1 antibody |
Information sourced from Uniprot.org