• Immunohistochemistry of rat spleen with Anti-TLR1 primary antibody (STJ503274) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-TLR1 antibody (200-250) (STJ503274)

SKU:
STJ503274-100

£441.50
Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TLR1 (200-250) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.67 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:20, 000
IP: 1:200
IHC: 1:100
ICC: 1:100
IF: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Tlr1
Gene ID: 21897
Uniprot ID: TLR1_MOUSE
Immunogen Region: 200-250
Immunogen: Synthetic peptide taken within amino acid region 200-250 on mouse toll-like receptor 1 protein.
Function Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen.
Protein Name Toll-Like Receptor 1
Toll/Interleukin-1 Receptor-Like Protein
Til
Cd Antigen Cd281
Database Links Reactome: R-MMU-1461957
Reactome: -MMU-5686938
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasmic Vesicle
Phagosome Membrane
Membrane Raft
Golgi Apparatus
Does Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial Ligand
In Response To Triacylated Lipoproteins
Tlr2:Tlr1 Heterodimers Are Recruited In Lipid Rafts
This Recruitment Determine The Intracellular Targeting To The Golgi Apparatus
Alternative Antibody Names Anti-Toll-Like Receptor 1 antibody
Anti-Toll/Interleukin-1 Receptor-Like Protein antibody
Anti-Til antibody
Anti-Cd Antigen Cd281 antibody
Anti-Tlr1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance