• Western blot analysis of lysates from COLO cells, using TLK2 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HeLa cells using TLK2 antibody.
  • Western blot analysis of various cells using TLK2 Polyclonal Antibody. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-TLK2 antibody (191-240 aa) (STJ96039)

SKU:
STJ96039

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Serine/threonine-protein kinase tousled-like 2 (191-240 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
ELISA 2000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TLK2
Gene ID: 11011
Uniprot ID: TLK2_HUMAN
Immunogen Region: 191-240 aa
Specificity: TLK2 Polyclonal Antibody detects endogenous levels of TLK2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human TLK2 at the amino acid range 191-240
Post Translational Modifications Phosphorylated at Ser-750, probably by CHEK1. Autophosphorylated.phosphorylation promotes the assembly of higher order oligomers and enzymatic activity.
Function Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
Protein Name Serine/Threonine-Protein Kinase Tousled-Like 2
Hshpk
Pku-Alpha
Tousled-Like Kinase 2
Cellular Localisation Nucleus
Nucleoplasm
Cytoplasm
Perinuclear Region
Cytoskeleton
Colocalizes With The Cytoplasmic Intermediate Filament System During The G1 Phase Of The Cell Cycle
Present In The Perinuclear Region At S Phase And In The Nucleus At Late G2
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase Tousled-Like 2 antibody
Anti-Hshpk antibody
Anti-Pku-Alpha antibody
Anti-Tousled-Like Kinase 2 antibody
Anti-TLK2 antibody

Information sourced from Uniprot.org

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