| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Transducin-like enhancer protein 1 homolog (300-350 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TLE1 |
| Gene ID: |
7088 |
| Uniprot ID: |
TLE1_HUMAN |
| Immunogen Region: |
300-350 aa |
| Specificity: |
This antibody detects endogenous levels of TLE1 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human TLE1 at the amino acid range 300-350 |
| Post Translational Modifications | Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1. Ubiquitinated by XIAP/BIRC4. |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
| Protein Name | Transducin-Like Enhancer Protein 1E(Sp1 HomologEnhancer Of Split Groucho-Like Protein 1Esg1 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2122947Reactome: R-HSA-3769402Reactome: R-HSA-4641265 |
| Cellular Localisation | NucleusNuclear And Chromatin-AssociatedDepending On Isoforms And Phosphorylation StatusHyperphosphorylation Decreases The Affinity For Nuclear Components |
| Alternative Antibody Names | Anti-Transducin-Like Enhancer Protein 1 antibodyAnti-E(Sp1 Homolog antibodyAnti-Enhancer Of Split Groucho-Like Protein 1 antibodyAnti-Esg1 antibodyAnti-TLE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
