• STJ70798 (0. 3µg/ml) staining of A549 (A) and K562 (B) cell lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
  • STJ70798 (0. 3µg/ml) staining of Human colorectal cancer lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.

Anti-TIRAP antibody (Internal) (STJ70798)

SKU:
STJ70798-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-TIRAP (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.1-0.3µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: TIRAP
Gene ID: 114609
Uniprot ID: TIRAP_HUMAN
Immunogen Region: Internal
Accession Number: NP_001034750.1; NP_683708.1
Specificity: This antibody is expected to recognize both reported isoforms (NP_001034750.1 and NP_683708.1).
Immunogen Sequence: QTLLKKPKKRPNSPE
Post Translational Modifications Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation.
Function Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6).
Protein Name Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein
Tir Domain-Containing Adapter Protein
Adaptor Protein Wyatt
Myd88 Adapter-Like Protein
Myd88-2
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-166058
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Cellular Localisation Cytoplasm
Cell Membrane
Membrane
Colocalizes With Dab2ip At The Plasma Membrane
Alternative Antibody Names Anti-Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein antibody
Anti-Tir Domain-Containing Adapter Protein antibody
Anti-Adaptor Protein Wyatt antibody
Anti-Myd88 Adapter-Like Protein antibody
Anti-Myd88-2 antibody
Anti-TIRAP antibody
Anti-MAL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance