Anti-TIPRL antibody [3D11] (STJA0032639)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenFull length human recombinant protein of human TIPRL produced in 293T cell.
General Information
| Short Description | Mouse monoclonal anti-TIPRL for use in WB and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3D11 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 0.79 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000FC 1:50-1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TIPRL |
| Gene ID | 261726 |
| Uniprot ID | TIPRL_HUMAN |
| Immunogen | Full length human recombinant protein of human TIPRL produced in 293T cell. |
Additional Info
| Function | May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex.the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. |
| Protein Name | Tip41-Like ProteinPutative Mapk-Activating Protein Pm10Type 2a-Interacting ProteinTip |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tip41-Like Protein antibodyAnti-Putative Mapk-Activating Protein Pm10 antibodyAnti-Type 2a-Interacting Protein antibodyAnti-Tip antibodyAnti-TIPRL antibody |
Information sourced from Uniprot.org