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Anti-TIMP1 antibody [SM5019] (STJA0005019)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenSynthesized peptide derived from human TIMP1
General Information
| Short Description | Mouse monoclonal anti-TIMP1 for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5019 |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC/IF (H) 1:200-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | TIMP1 |
| Gene ID | 7076 |
| Uniprot ID | TIMP1_HUMAN |
| Immunogen | Synthesized peptide derived from human TIMP1 |
Additional Info
| Post Translational Modifications | The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated. |
| Function | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro.but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. |
| Protein Name | Metalloproteinase Inhibitor 1Erythroid-Potentiating ActivityEpaFibroblast Collagenase InhibitorCollagenase InhibitorTissue Inhibitor Of Metalloproteinases 1Timp-1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1592389Reactome: R-HSA-381426Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-8957275Reactome: R-HSA-9839383 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Metalloproteinase Inhibitor 1 antibodyAnti-Erythroid-Potentiating Activity antibodyAnti-Epa antibodyAnti-Fibroblast Collagenase Inhibitor antibodyAnti-Collagenase Inhibitor antibodyAnti-Tissue Inhibitor Of Metalloproteinases 1 antibodyAnti-Timp-1 antibodyAnti-TIMP1 antibodyAnti-CLGI antibodyAnti-TIMP antibody |
Information sourced from Uniprot.org