Anti-TIMD4/TIM-4 antibody [RMT4-53] {APC} (STJA0029782)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationAPC
IsotypeIgG2ak
General Information
| Short Description | Rat monoclonal T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4 antibody for use in FC in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rat |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RMT4-53 |
| Isotype | IgG2ak |
| Conjugation | APC |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | Timd4 |
| Gene ID | 276891 |
| Uniprot ID | TIMD4_MOUSE |
Additional Info
| Function | Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells. Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion. Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism. |
| Protein Name | T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4Timd-4Spleen - Mucin-Containing - Knockout Of Lymphotoxin ProteinSmucklerT-Cell Immunoglobulin Mucin Receptor 4Tim-4T-Cell Membrane Protein 4 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4 antibodyAnti-Timd-4 antibodyAnti-Spleen - Mucin-Containing - Knockout Of Lymphotoxin Protein antibodyAnti-Smuckler antibodyAnti-T-Cell Immunoglobulin Mucin Receptor 4 antibodyAnti-Tim-4 antibodyAnti-T-Cell Membrane Protein 4 antibodyAnti-Timd4 antibodyAnti-Tim4 antibody |
Information sourced from Uniprot.org