Anti-TIM-1 antibody (Internal) (STJ73133)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TIM-1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 52kDa band observed in Human Kidney, Testis and Uterus lysates (calculated MW of 39.2kDa according to NP_036338.2). This molecular weight is routinely observed by other sources. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | HAVCR1 |
| Gene ID | 26762 |
| Uniprot ID | HAVR1_HUMAN |
| Immunogen Region | Internal |
| Immunogen Sequence | THVTYRKDTRYK |
| Specificity | The immunizing peptide represents part of the extracellular domain. Reported variants represent identical protein: NP_001166864.1, NP_001092884.1, NP_036338.2 |
Additional Info
| Post Translational Modifications | Ubiquitinated at two lysine residues Lys-338 and Lys-346 on its cytoplasmic domain. Ubiquitination promotes receptor endocytosis and target receptors for lysosomal degradation and termination of receptor signaling. (Microbial infection) Ubiquitination is required for Dengue virus endocytosis. |
| Function | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation. May play a role in kidney injury and repair. (Microbial infection) Acts as a receptor for Hepatitis A virus. (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane. Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP. (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane. TIM1 and Dengue virus are co-internalized during virus entry. (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. (Microbial infection) Plays a positive role in Chikungunya virus cell entry. |
| Protein Name | Hepatitis A Virus Cellular Receptor 1Havcr-1Kidney Injury Molecule 1Kim-1T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1Timd-1T-Cell Immunoglobulin Mucin Receptor 1TimTim-1T-Cell Membrane Protein 1Cd Antigen Cd365 |
| Database Links | Reactome: R-HSA-9694614 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Hepatitis A Virus Cellular Receptor 1 antibodyAnti-Havcr-1 antibodyAnti-Kidney Injury Molecule 1 antibodyAnti-Kim-1 antibodyAnti-T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1 antibodyAnti-Timd-1 antibodyAnti-T-Cell Immunoglobulin Mucin Receptor 1 antibodyAnti-Tim antibodyAnti-Tim-1 antibodyAnti-T-Cell Membrane Protein 1 antibodyAnti-Cd Antigen Cd365 antibodyAnti-HAVCR1 antibodyAnti-KIM1 antibodyAnti-TIM1 antibodyAnti-TIMD1 antibody |
Information sourced from Uniprot.org