Anti-TIAM2 antibody [R09-8G7] (STJA0034930)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human TIAM2
General Information
| Short Description | Rabbit monoclonal anti-TIAM2 for use in WB, IHC-F, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-F/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-8G7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TIAM2 |
| Gene ID | 26230 |
| Uniprot ID | TIAM2_HUMAN |
| Immunogen | Recombinant protein of human TIAM2 |
Additional Info
| Tissue Specificity | Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis. |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth. |
| Function | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor Tiam2Sif And Tiam1-Like Exchange FactorT-Lymphoma Invasion And Metastasis-Inducing Protein 2Tiam-2 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-1989781Reactome: R-HSA-416482Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCell ProjectionLamellipodiumFilopodiumGrowth ConeNeuron ProjectionPerikaryon |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor Tiam2 antibodyAnti-Sif And Tiam1-Like Exchange Factor antibodyAnti-T-Lymphoma Invasion And Metastasis-Inducing Protein 2 antibodyAnti-Tiam-2 antibodyAnti-TIAM2 antibodyAnti-KIAA2016 antibodyAnti-STEF antibody |
Information sourced from Uniprot.org