Anti-TIAM1 antibody (STJ192977)

SKU:
STJ192977

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Rho guanine nucleotide exchange factor TIAM1 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TIAM1
Gene ID: 7074
Uniprot ID: TIAM1_HUMAN
Specificity: TIAM1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Ubiquitinated. Undergoes 'Lys-48' ubiquitination at Lys-1404 and Lys-1420 by a CUL3(KBTBD6/7) E3 ubiquitin ligase complex composed of CUL3, RBX1, KBTBD6 and KBTBD7. 'Lys-48' ubiquitination at Lys-1404 and Lys-1420 triggers proteasomal degradation. Ubiquitination at Lys-1404 and Lys-1420 by CUL3(KBTBD6/7) also requires the membrane-associated protein GABARAP and may therefore be spatially restricted within the cell.
Function Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration.
Protein Name Rho Guanine Nucleotide Exchange Factor Tiam1
T-Lymphoma Invasion And Metastasis-Inducing Protein 1
Tiam-1
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-3928662
Reactome: R-HSA-3928665
Reactome: R-HSA-416482
Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013423
Reactome: R-HSA-9032845
Cellular Localisation Cell Junction
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Detected At The Boundary Between Cells With Actin-Rich Protrusions
Presence Of Krit1
Cdh5 And Rap1b Is Required For Its Localization To The Cell Junction
Alternative Antibody Names Anti-Rho Guanine Nucleotide Exchange Factor Tiam1 antibody
Anti-T-Lymphoma Invasion And Metastasis-Inducing Protein 1 antibody
Anti-Tiam-1 antibody
Anti-TIAM1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance