Anti-Thyroid Hormone Receptor alpha antibody [R07-3J8] (STJA0037228)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human THRA
General Information
| Short Description | Rabbit monoclonal anti-Thyroid Hormone Receptor alpha for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-3J8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | THRA |
| Gene ID | 7067 |
| Uniprot ID | THA_HUMAN |
| Immunogen | A synthesized peptide derived from human THRA |
Additional Info
| Function | Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. |
| Protein Name | Thyroid Hormone Receptor AlphaNuclear Receptor Subfamily 1 Group A Member 1V-Erba-Related Protein 7Ear-7C-Erba-1C-Erba-Alpha |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 P10827-2 |
| Cellular Localisation | NucleusIsoform Alpha-2: CytoplasmWhen Overexpressed Found In The Cytoplasm Where It Colocalizes With Tacc1 |
| Alternative Antibody Names | Anti-Thyroid Hormone Receptor Alpha antibodyAnti-Nuclear Receptor Subfamily 1 Group A Member 1 antibodyAnti-V-Erba-Related Protein 7 antibodyAnti-Ear-7 antibodyAnti-C-Erba-1 antibodyAnti-C-Erba-Alpha antibodyAnti-THRA antibodyAnti-EAR7 antibodyAnti-ERBA1 antibodyAnti-NR1A1 antibodyAnti-THRA1 antibodyAnti-THRA2 antibody |
Information sourced from Uniprot.org