| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-THOC7 (1-204) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
THOC7 |
| Gene ID: |
80145 |
| Uniprot ID: |
THOC7_HUMAN |
| Immunogen Region: |
1-204 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-204 of human THOC7 (NP_079351.2). |
| Immunogen Sequence: |
MGAVTDDEVIRKRLLIDGDG AGDDRRINLLVKSFIKWCNS GSQEEGYSQYQRMLSTLSQC EFSMGKTLLVYDMNLREMEN YEKIYKEIECSIAGAHEKIA ECKKQILQAKRIRKNRQEYD ALAKVIQHHPDRHETLKELE ALGKELEHLSHIKESVEDKL ELRRKQFHVLLSTIHELQQT LENDEKLSEVEEAQEASMET DPKP |
| Function | Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. |
| Protein Name | Tho Complex Subunit 7 HomologFunctional Spliceosome-Associated Protein 24Fsap24Ngg1-Interacting Factor 3-Like Protein 1-Binding Protein 1Nif3l1-Binding Protein 1Htrex30 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72187Reactome: R-HSA-73856 |
| Cellular Localisation | CytoplasmNucleusNucleus SpeckleInteraction With Thoc5 Is Required For Nuclear Localization |
| Alternative Antibody Names | Anti-Tho Complex Subunit 7 Homolog antibodyAnti-Functional Spliceosome-Associated Protein 24 antibodyAnti-Fsap24 antibodyAnti-Ngg1-Interacting Factor 3-Like Protein 1-Binding Protein 1 antibodyAnti-Nif3l1-Binding Protein 1 antibodyAnti-Htrex30 antibodyAnti-THOC7 antibodyAnti-NIF3L1BP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
