| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-THOC2 (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
THOC2 |
| Gene ID: |
57187 |
| Uniprot ID: |
THOC2_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human THOC2 (NP_001075019.1). |
| Immunogen Sequence: |
MAAAAVVVPAEWIKNWEKSG RGEFLHLCRILSENKSHDSS TYRDFQQALYELSYHVIKGN LKHEQASNVLSDISEFREDM PSILADVFCILDIETNCLEE KSKRDYFTQLVLACLYLVSD TVLKERLDPETLESLGLIKQ SQQFNQKSVKIKTKLFYKQQ KFNLLREENEGYAKLIAELG QDLSGSITSDLILENIKSLI GCFNLDPNRVLDVILEVFEC RPEHDDFFISLLESYMSMC |
| Tissue Specificity | Expressed in the hippocampus and the cerebral cortex. |
| Function | Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. |
| Protein Name | Tho Complex Subunit 2Tho2Htrex120 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72187Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Tho Complex Subunit 2 antibodyAnti-Tho2 antibodyAnti-Htrex120 antibodyAnti-THOC2 antibodyAnti-CXorf3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
