| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Thioredoxin Reductase 1 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 60kDa band observed in Human Placenta lysates (predicted MW of 57kDa according to NP_003321). Recommended for use at 0.1-1µg/ml.IHC: Paraffin embedded Human Testis and Sple |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | TXNRD1 |
| Gene ID: | 7296 |
| Uniprot ID: | TRXR1_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_003321.2; NP_877393.1; NP_877419.1; NP_877420.1; NP_001087240.1 |
| Specificity: | This antibody is expected to recognise reported isoform 1 (NP_003321.2) , isoform 2 (NP_877393.1; NP_877419.1; NP_877420.1) and isoform 3 (NP_001087240.1) |
| Immunogen Sequence: | TKRSGASILQAGC |
| Post Translational Modifications | Isoform 5: The N-terminus is blocked. ISGylated. |
| Function | Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2). Isoform 1: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. Isoform 5: Enhances the transcriptional activity of the estrogen receptor ESR2 only. Mediates cell death induced by a combination of interferon-beta and retinoic acid. |
| Protein Name | Thioredoxin Reductase 1 - CytoplasmicTrGene Associated With Retinoic And Interferon-Induced Mortality 12 ProteinGrim-12Gene Associated With Retinoic And Ifn-Induced Mortality 12 ProteinKm-102-Derived Reductase-Like FactorPeroxidase Txnrd1Thioredoxin Reductase Tr1 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2408550Reactome: R-HSA-3299685Reactome: R-HSA-499943Reactome: R-HSA-5263617Reactome: R-HSA-5336415Reactome: R-HSA-5628897Reactome: R-HSA-9818027 |
| Cellular Localisation | Isoform 1: CytoplasmIsoform 4: CytoplasmNucleusIsoform 5: Cytoplasm |
| Alternative Antibody Names | Anti-Thioredoxin Reductase 1 - Cytoplasmic antibodyAnti-Tr antibodyAnti-Gene Associated With Retinoic And Interferon-Induced Mortality 12 Protein antibodyAnti-Grim-12 antibodyAnti-Gene Associated With Retinoic And Ifn-Induced Mortality 12 Protein antibodyAnti-Km-102-Derived Reductase-Like Factor antibodyAnti-Peroxidase Txnrd1 antibodyAnti-Thioredoxin Reductase Tr1 antibodyAnti-TXNRD1 antibodyAnti-GRIM12 antibodyAnti-KDRF antibody |
Information sourced from Uniprot.org
