Anti-Thioredoxin Interacting Protein antibody [R05-7I6] (STJA0036630)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human TXNIP
General Information
| Short Description | Rabbit monoclonal anti-Thioredoxin Interacting Protein for use in WB, IHC-P, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-7I6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TXNIP |
| Gene ID | 10628 |
| Uniprot ID | TXNIP_HUMAN |
| Immunogen | A synthesized peptide derived from human TXNIP |
Additional Info
| Post Translational Modifications | Ubiquitinated.undergoes heterotypic 'Lys-48'-/'Lys-63'-branched polyubiquitination catalyzed by ITCH and UBR5 resulting in proteasomal degradation. Deubiquitinated by USP5, leading to TXNIP stabilization. |
| Function | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| Protein Name | Thioredoxin-Interacting ProteinThioredoxin-Binding Protein 2Vitamin D3 Up-Regulated Protein 1 |
| Database Links | Reactome: R-HSA-844456Reactome: R-HSA-9617629Reactome: R-HSA-9660826Reactome: R-HSA-9707564 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Thioredoxin-Interacting Protein antibodyAnti-Thioredoxin-Binding Protein 2 antibodyAnti-Vitamin D3 Up-Regulated Protein 1 antibodyAnti-TXNIP antibodyAnti-VDUP1 antibody |
Information sourced from Uniprot.org