Anti-THG1L antibody (STJA0008111)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human THG1L
General Information
| Short Description | Rabbit polyclonal anti-Probable tRNAHis guanylyltransferase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | THG1L |
| Gene ID | 54974 |
| Uniprot ID | THG1_HUMAN |
| Immunogen | Synthesized peptide derived from human THG1L |
| Specificity | This antibody detects endogenous levels of THG1L at Human, Mouse, Rat |
Additional Info
| Function | Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress. |
| Protein Name | Probable Trna(His GuanylyltransferaseInduced In High Glucose-1Ihg-1Interphase Cytoplasmic Foci Protein 45Trna-Histidine Guanylyltransferase |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmMitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Probable Trna(His Guanylyltransferase antibodyAnti-Induced In High Glucose-1 antibodyAnti-Ihg-1 antibodyAnti-Interphase Cytoplasmic Foci Protein 45 antibodyAnti-Trna-Histidine Guanylyltransferase antibodyAnti-THG1L antibodyAnti-ICF45 antibody |
Information sourced from Uniprot.org