| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TGM3 (1-180) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:10-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TGM3 |
| Gene ID: |
7053 |
| Uniprot ID: |
TGM3_HUMAN |
| Immunogen Region: |
1-180 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human TGM3 (NP_003236.3). |
| Immunogen Sequence: |
MAALGVQSINWQTAFNRQAH HTDKFSSQELILRRGQNFQV LMIMNKGLGSNERLEFIVST GPYPSESAMTKAVFPLSNGS SGGWSAVLQASNGNTLTISI SSPASAPIGRYTMALQIFSQ GGISSVKLGTFILLFNPWLN VDSVFMGNHAEREEYVQEDA GIIFVGSTNRIGMIGWNFGQ |
| Post Translational Modifications | Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 or between Pro-465 and Phe-466. Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS, but not by CTSB, CTSD nor CTSV. |
| Function | Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. |
| Protein Name | Protein-Glutamine Gamma-Glutamyltransferase ETransglutaminase ETg(ETgeTgase ETransglutaminase-3Tgase-3 Cleaved Into - Protein-Glutamine Gamma-Glutamyltransferase E 50 Kda Catalytic Chain - Protein-Glutamine Gamma-Glutamyltransferase E 27 Kda Non-Catalytic Chain |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein-Glutamine Gamma-Glutamyltransferase E antibodyAnti-Transglutaminase E antibodyAnti-Tg(E antibodyAnti-Tge antibodyAnti-Tgase E antibodyAnti-Transglutaminase-3 antibodyAnti-Tgase-3 Cleaved Into - Protein-Glutamine Gamma-Glutamyltransferase E 50 Kda Catalytic Chain - Protein-Glutamine Gamma-Glutamyltransferase E 27 Kda Non-Catalytic Chain antibodyAnti-TGM3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
