Anti-TGFBI antibody (550-650) (STJ25831)

Name: Anti-TGFBI antibody (550-650) (STJ25831)
SKU: STJ25831
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ25831

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Short Description	Rabbit polyclonal TGFBI (550-650) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	TGFBI
Gene ID	7045
Uniprot ID	BGH3_HUMAN
Immunogen Region	550-650
Immunogen Sequence	LPPRERSRLLGDAKELANIL KYHIGDEILVSGGIGALVRL KSLQGDKLEVSLKNNVVSVN KEPVAEPDIMATNGVVHVIT NVLQPPANRPQERGDELADS A
Specificity	A synthetic peptide corresponding to a sequence within amino acids 550-650 of human TGF beta induced (TGFBI) (NP_000349.1).

Tissue Specificity	Highly expressed in the corneal epithelium. Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Post Translational Modifications	Gamma-carboxylation is controversial. Gamma-carboxyglutamated.gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation.these residues may be required for binding to calcium. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues. The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain.
Function	Plays a role in cell adhesion. May play a role in cell-collagen interactions.
Protein Name	Transforming Growth Factor-Beta-Induced Protein Ig-H3 Beta Ig-H3 Kerato-Epithelin Rgd-Containing Collagen-Associated Protein Rgd-Cap
Database Links	Reactome: R-HSA-977225
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix May Be Associated Both With Microfibrils And With The Cell Surface
Alternative Antibody Names	Anti-Transforming Growth Factor-Beta-Induced Protein Ig-H3 antibody Anti-Beta Ig-H3 antibody Anti-Kerato-Epithelin antibody Anti-Rgd-Containing Collagen-Associated Protein antibody Anti-Rgd-Cap antibody Anti-TGFBI antibody Anti-BIGH3 antibody

Information sourced from Uniprot.org