Anti-Tensin 1/TNS1 antibody (C-Term) (STJ70045)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Tensin 1/TNS1 (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Preliminary experiments in Human Heart, Kidney and Skeletal Muscle lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any f |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TNS1 |
| Gene ID | 7145 |
| Uniprot ID | TENS1_HUMAN |
| Accession Number | NP_072174.3 |
| Immunogen Region | C-Term |
| Immunogen Sequence | VSKVMLNAGQKR |
Additional Info
| Post Translational Modifications | Extensively phosphorylated on serine and threonine residues in a p38 MAPK-dependent manner which reduces interaction with DLC1 and increases interaction with tyrosine-phosphorylated proteins including BCAR1/p130cas and PTK2/FAK. The majority of the phosphorylated Ser/Thr residues are immediately adjacent to a proline residue. Also phosphorylated on tyrosine residues. Rapidly cleaved by calpain II. |
| Function | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition. Enhances RHOA activation in the presence of DLC1. Plays a role in cell polarization and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton. |
| Protein Name | Tensin-1 |
| Cellular Localisation | Cell SurfaceCell JunctionFocal AdhesionCytoplasmCytoskeletonLocalizes To Both Focal Adhesions And Fibrillar AdhesionsLocalized At The Cell Periphery Preferentially To Fibrillar Adhesions Rather Than To Focal AdhesionsTranslocates From The Cell Edge To The Cell Center In An Itgb1bp1-Dependent Manner |
| Alternative Antibody Names | Anti-Tensin-1 antibodyAnti-TNS1 antibodyAnti-TNS antibody |
Information sourced from Uniprot.org