Anti-TEM8/Anthrax Toxin Receptor 1 antibody (C-Term) (STJ70589)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TEM8/Anthrax Toxin Receptor 1 (C-Term) is suitable for use in ELISA and Immunofluorescence research applications. |
| Applications | Pep-ELISA/IF |
| Host | Goat |
| Reactivity | Human/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Preliminary testing showed a band at approx 65-70kDa in lysate of cell lines A431 and U2OS after 1-2µg/ml antibody staining (calculated MW of 62.8kDa according to NP_115584.1). This ba |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ANTXR1 |
| Gene ID | 84168 |
| Uniprot ID | ANTR1_HUMAN |
| Accession Number | NP_115584.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | RAPPPSRPPPRPSV |
| Specificity | This antibody is expected to recognise variant 1 (NP_115584) only. |
Additional Info
| Function | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. |
| Protein Name | Anthrax Toxin Receptor 1Tumor Endothelial Marker 8 |
| Database Links | Reactome: R-HSA-5210891 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionLamellipodium MembraneFilopodium MembraneAt The Membrane Of Lamellipodia And At The Tip Of Actin-Enriched FilopodiaColocalizes With Actin At The Base Of Lamellipodia |
| Alternative Antibody Names | Anti-Anthrax Toxin Receptor 1 antibodyAnti-Tumor Endothelial Marker 8 antibodyAnti-ANTXR1 antibodyAnti-ATR antibodyAnti-TEM8 antibody |
Information sourced from Uniprot.org