| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TELO2 (450-550) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TELO2 |
| Gene ID: |
9894 |
| Uniprot ID: |
TELO2_HUMAN |
| Immunogen Region: |
450-550 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 450-550 of human TELO2 (NP_057195.2). |
| Immunogen Sequence: |
ASEAGTSLVPATAEPPAETP AEIVDGGVPQAQLAGSDSDL DSDDEFVPYDMSGDRELKSS KAPAYVRDCVEALTTSEDIE RWEAALRALEGLVYRSPTAT R |
| Post Translational Modifications | Hydroxylation by PHD3 is required for a proper interaction with ATR, and activation of the ATR/CHK1/p53 pathway following DNA damage. Phosphorylated at Ser-485 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2.leading to selective ubiquitination of mTORC1-associated protein. Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1. |
| Function | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. |
| Protein Name | Telomere Length Regulation Protein Tel2 HomologProtein Clk-2 HomologHclk2 |
| Cellular Localisation | CytoplasmMembraneNucleusChromosomeTelomere |
| Alternative Antibody Names | Anti-Telomere Length Regulation Protein Tel2 Homolog antibodyAnti-Protein Clk-2 Homolog antibodyAnti-Hclk2 antibodyAnti-TELO2 antibodyAnti-KIAA0683 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
