| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/IP/ELISA/ChIP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 IP:0.5 Mu g-4 Mu g antibody for 400 Mu g-600 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your speci |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TEAD1 |
| Gene ID: | 7003 |
| Uniprot ID: | TEAD1_HUMAN |
| Immunogen Region: | 135-215 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 135-215 of human TEAD1 (NP_068780.2). |
| Immunogen Sequence: | AIHNKLGLPGIPRPTFPGAP GFWPGMIQTGQPGSSQDVKP FVQQAYPIQPAVTAPIPGFE PASAPAPSVPAWQGRSIGTT K |
| Tissue Specificity | Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. |
| Post Translational Modifications | Lactylation by AARS1 promotes nuclear localization and stabilization of YAP1, leading to increased Hippo signaling pathway. Delactylated by SIRT1. |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. |
| Protein Name | Transcriptional Enhancer Factor Tef-1 Ntef-1 Protein Gt-Iic Tea Domain Family Member 1 Tead-1 Transcription Factor 13 Tcf-13 |
| Database Links | Reactome: R-HSA-2032785 Reactome: R-HSA-8951671 Reactome: R-HSA-9619665 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Enhancer Factor Tef-1 antibody Anti-Ntef-1 antibody Anti-Protein Gt-Iic antibody Anti-Tea Domain Family Member 1 antibody Anti-Tead-1 antibody Anti-Transcription Factor 13 antibody Anti-Tcf-13 antibody Anti-TEAD1 antibody Anti-TCF13 antibody Anti-TEF1 antibody |
Information sourced from Uniprot.org