Anti-TDRKH IP antibody [SAA0235] (STJA0018750)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal Tudor And Kh Domain-Containing Protein antibody for use in ELISA, IF, IP and IP-MS in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/IF/IP/IP-MS |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0235 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | TDRKH |
| Gene ID | 11022 |
| Uniprot ID | TDRKH_HUMAN |
Additional Info
| Function | Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. |
| Protein Name | Tudor And Kh Domain-Containing ProteinTudor Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmMitochondrionProbable Component Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisColocalizes With Pi- And Pip-BodiesA Subset Of The Nuage Which Contains Secondary PirnasAssociated With Mitochondria In The Germline |
| Alternative Antibody Names | Anti-Tudor And Kh Domain-Containing Protein antibodyAnti-Tudor Domain-Containing Protein 2 antibodyAnti-TDRKH antibodyAnti-TDRD2 antibody |
Information sourced from Uniprot.org