Anti-TDRD3 antibody (1-220) (STJ27796)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TDRD3 (1-220) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TDRD3 |
| Gene ID | 81550 |
| Uniprot ID | TDRD3_HUMAN |
| Immunogen Region | 1-220 |
| Immunogen Sequence | MLRLQMTDGHISCTAVEFSY MSKISLNTPPGTKVKLSGIV DIKNGFLLLNDSNTTVLGGE VEHLIEKWELQRSLSKHNRS NIGTEGGPPPFVPFGQKCVS HVQVDSRELDRRKTLQVTMP VKPTNDNDEFEKQRTAAIAE VAKSKETKTFGGGGGGARSN LNMNAAGNRNREVLQKEKST KSEGKHEGVYRELVDEKALK HITEMGFSKEASRQALMDNG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TDRD3 (NP_110421.1). |
Additional Info
| Tissue Specificity | Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Probably cleaved by enteroviral 2A proteinase. |
| Function | Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1. |
| Protein Name | Tudor Domain-Containing Protein 3 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicAssociated With Actively Translating PolyribosomesComponent Of Stress Granules |
| Alternative Antibody Names | Anti-Tudor Domain-Containing Protein 3 antibodyAnti-TDRD3 antibody |
Information sourced from Uniprot.org