| Host: |
Rabbit |
| Applications: |
ELISA/IHC/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TDRD1 (570-605) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.52-0.53 µg/µl |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
TDRD1 |
| Gene ID: |
56165 |
| Uniprot ID: |
TDRD1_HUMAN |
| Immunogen Region: |
570-605 |
| Immunogen: |
Synthetic peptide taken within amino acid region 570-605 on TDRD1 protein. |
| Tissue Specificity | Testis and ovary specific. Also expressed in several cancers. |
| Function | Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. |
| Protein Name | Tudor Domain-Containing Protein 1Cancer/Testis Antigen 41.1Ct41.1 |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmComponent Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisAlso Present In Chromatoid Body |
| Alternative Antibody Names | Anti-Tudor Domain-Containing Protein 1 antibodyAnti-Cancer/Testis Antigen 41.1 antibodyAnti-Ct41.1 antibodyAnti-TDRD1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
