• Western blot analysis of lysates from mouse testis, using TDRD1 Rabbit polyclonal antibody (STJ114748) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-TDRD1 antibody (25-125) (STJ114748)

SKU:
STJ114748

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TDRD1 (25-125) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TDRD1
Gene ID: 56165
Uniprot ID: TDRD1_HUMAN
Immunogen Region: 25-125
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-125 of human TDRD1 (NP_942090.1).
Immunogen Sequence: PFNFEKNENKLPPHESLRSP GTLPNHPNFRLKSSENGNKK NNFLLCEQTKQYLASQEDNS VSSNPNGINGEVVGSKGDRK KLPAGNSVSPPSAESNSPPK E
Tissue Specificity Testis and ovary specific. Also expressed in several cancers.
Function Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.
Protein Name Tudor Domain-Containing Protein 1
Cancer/Testis Antigen 41.1
Ct41.1
Database Links Reactome: R-HSA-5601884
Cellular Localisation Cytoplasm
Component Of The Meiotic Nuage
Also Named P Granule
A Germ-Cell-Specific Organelle Required To Repress Transposon Activity During Meiosis
Also Present In Chromatoid Body
Alternative Antibody Names Anti-Tudor Domain-Containing Protein 1 antibody
Anti-Cancer/Testis Antigen 41.1 antibody
Anti-Ct41.1 antibody
Anti-TDRD1 antibody

Information sourced from Uniprot.org

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