Anti-TDRD1 antibody (25-125) (STJ114748)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TDRD1 (25-125) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TDRD1 |
| Gene ID | 56165 |
| Uniprot ID | TDRD1_HUMAN |
| Immunogen Region | 25-125 |
| Immunogen Sequence | PFNFEKNENKLPPHESLRSP GTLPNHPNFRLKSSENGNKK NNFLLCEQTKQYLASQEDNS VSSNPNGINGEVVGSKGDRK KLPAGNSVSPPSAESNSPPK E |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 25-125 of human TDRD1 (NP_942090.1). |
Additional Info
| Tissue Specificity | Testis and ovary specific. Also expressed in several cancers. |
| Function | Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. |
| Protein Name | Tudor Domain-Containing Protein 1Cancer/Testis Antigen 41.1Ct41.1 |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmComponent Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisAlso Present In Chromatoid Body |
| Alternative Antibody Names | Anti-Tudor Domain-Containing Protein 1 antibodyAnti-Cancer/Testis Antigen 41.1 antibodyAnti-Ct41.1 antibodyAnti-TDRD1 antibody |
Information sourced from Uniprot.org