Anti-TCR Gamma/Delta antibody [UC7-13D5] (STJA0001778)
SPECIFICATIONS
ClonalityMonoclonal
HostArmenian Hamster
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Armenian Hamster monoclonal anti-TCR Gamma/Delta for use in FC and IP in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IP |
| Host | Armenian Hamster |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | UC7-13D5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Formulation | PBS with 0.05% Proclin300 |
| Storage Instruction | This product can be stored at 2-8°C for 12 months. Do not freeze. |
Target Information
Additional Info
| Background | T cell receptor (TCR) is a heterodimer consisting of an Alpha and a Beta chain (TCR Alpha/Beta ) or a Gamma and a Delta chain (TCR Gamma/Delta ). TCR Gamma/Delta belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR Gamma/Delta associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most Gamma/Delta T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR Gamma/Delta have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that Gamma/Delta T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-Gamma/Delta-bearing T cells in vitro, and to deplete peripheral TCR-Gamma/Delta-bearing T cells in vivo. |
Information sourced from Uniprot.org