| Host: | Rabbit |
| Applications: | WB/IHC-P/ICC/IF/IP |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-TCP 1 alpha for use in WB, IHC-P, ICC, IF and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R09-5M8 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:50 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | TCP1 |
| Gene ID: | 6950 |
| Uniprot ID: | TCPA_HUMAN |
| Immunogen: | A synthesized peptide derived from human TCP1 alpha |
| Function | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. |
| Protein Name | T-Complex Protein 1 Subunit AlphaTcp-1-AlphaCct-AlphaChaperonin Containing T-Complex Polypeptide 1 Subunit 1 |
| Database Links | Reactome: R-HSA-389957Reactome: R-HSA-389960Reactome: R-HSA-390450Reactome: R-HSA-390471Reactome: R-HSA-5620922Reactome: R-HSA-6814122Reactome: R-HSA-8950505 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Antibody Names | Anti-T-Complex Protein 1 Subunit Alpha antibodyAnti-Tcp-1-Alpha antibodyAnti-Cct-Alpha antibodyAnti-Chaperonin Containing T-Complex Polypeptide 1 Subunit 1 antibodyAnti-TCP1 antibodyAnti-CCT1 antibodyAnti-CCTA antibody |
Information sourced from Uniprot.org