Anti-TCL1 antibody [EP105] (STJ16101449)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal antibody anti-TCL1 is suitable for use in Immunohistochemistry research applications. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | EP105 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Dilution Range | IHC-P 1:100-1:200 |
| Formulation | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C upon receipt. |
Target Information
Additional Info
| Background | T-cell leukemia/lymphoma protein 1A (TCL1) is a member of theTCL1 family and enhances the phosphorylation and activation ofAKT1, AKT2 and AKT3. TCL1promotes the nuclear translocation ofAKT1 and enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. The expression of TCL1 is restricted to lymphoid cells. It is expressed early in lymphocyte differentiation. Strong expression ofTCL1 is found in a subset of mantle zone B lymphocytes and is expressed to a lesser extent by follicle center cells. In B cell neoplasia, TCL1 immunoreactivity is found in the majority of B cell lymphomas including lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, Burkitt lymphoma, diffuse large B-cell lymphoma (60%) , and primary cutaneous B cell lymphoma (55%). The expression of theTCL1genecharacterizes low-grade B cell lymphomas. |
Information sourced from Uniprot.org