Anti-TCIRG1 antibody (1-130) (STJ117577)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TCIRG1 (1-130) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TCIRG1 |
| Gene ID | 10312 |
| Uniprot ID | VPP3_HUMAN |
| Immunogen Region | 1-130 |
| Immunogen Sequence | MGSMFRSEEVALVQLFLPTA AAYTCVSRLGELGLVEFRDL NASVSAFQRRFVVDVRRCEE LEKTFTFLQEEVRRAGLVLP PPKGRLPAPPPRDLLRIQEE TERLAQELRDVRGNQQALRA QLHQLQLHAA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human TCIRG1 (NP_006010.2). |
Additional Info
| Tissue Specificity | Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus. |
| Function | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Seems to be directly involved in T-cell activation. |
| Protein Name | V-Type Proton Atpase 116 Kda Subunit A 3V-Atpase 116 Kda Subunit A 3Osteoclastic Proton Pump 116 Kda SubunitOc-116 KdaOc116T-Cell Immune Regulator 1T-Cell Immune Response Cdna7 ProteinTirc7Vacuolar Proton Translocating Atpase 116 Kda Subunit A Isoform 3 |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-6798695Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-9639288Reactome: R-HSA-983712 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-V-Type Proton Atpase 116 Kda Subunit A 3 antibodyAnti-V-Atpase 116 Kda Subunit A 3 antibodyAnti-Osteoclastic Proton Pump 116 Kda Subunit antibodyAnti-Oc-116 Kda antibodyAnti-Oc116 antibodyAnti-T-Cell Immune Regulator 1 antibodyAnti-T-Cell Immune Response Cdna7 Protein antibodyAnti-Tirc7 antibodyAnti-Vacuolar Proton Translocating Atpase 116 Kda Subunit A Isoform 3 antibodyAnti-TCIRG1 antibodyAnti-ATP6N1C antibodyAnti-ATP6V0A3 antibody |
Information sourced from Uniprot.org