Anti-TCHP antibody (STJ191797)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Trichoplein keratin filament-binding protein for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TCHP |
| Gene ID | 84260 |
| Uniprot ID | TCHP_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | TCHP Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis. |
| Function | Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis. |
| Protein Name | Trichoplein Keratin Filament-Binding ProteinProtein TchpMitochondrial Protein With Oncostatic ActivityMitostatinTumor Suppressor Protein |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneMitochondrionCell JunctionDesmosomeMicrotubule Organizing CenterCentrosome |
| Alternative Antibody Names | Anti-Trichoplein Keratin Filament-Binding Protein antibodyAnti-Protein Tchp antibodyAnti-Mitochondrial Protein With Oncostatic Activity antibodyAnti-Mitostatin antibodyAnti-Tumor Suppressor Protein antibodyAnti-TCHP antibody |
Information sourced from Uniprot.org