Anti-TCF4 antibody (1-210) (STJ25793)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TCF4 (1-210) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TCF4 |
| Gene ID | 6925 |
| Uniprot ID | ITF2_HUMAN |
| Immunogen Region | 1-210 |
| Immunogen Sequence | MHHQQRMAALGTDKELSDLL DFSAMFSPPVSSGKNGPTSL ASGHFTGSNVEDRSSSGSWG NGGHPSPSRNYGDGTPYDHM TSRDLGSHDNLSPPFVNSRI QSKTERGSYSSYGRESNLQG CHQQSLLGGDMDMGNPGTLS PTKPGSQYYQYSSNNPRRRP LHSSAMEVQTKKVRKVPPGL PSSVYAPSASTADYNRDSPG YPSSKPATST |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human TCF4 (NP_003190.1). |
Additional Info
| Tissue Specificity | Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain. |
| Function | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. |
| Protein Name | Transcription Factor 4Tcf-4Class B Basic Helix-Loop-Helix Protein 19Bhlhb19Immunoglobulin Transcription Factor 2Itf-2Sl3-3 Enhancer Factor 2Sef-2 |
| Database Links | Reactome: R-HSA-525793Reactome: R-HSA-9839394 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor 4 antibodyAnti-Tcf-4 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 19 antibodyAnti-Bhlhb19 antibodyAnti-Immunoglobulin Transcription Factor 2 antibodyAnti-Itf-2 antibodyAnti-Sl3-3 Enhancer Factor 2 antibodyAnti-Sef-2 antibodyAnti-TCF4 antibodyAnti-BHLHB19 antibodyAnti-ITF2 antibodyAnti-SEF2 antibody |
Information sourced from Uniprot.org