| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TCF4 |
| Gene ID: | 6925 |
| Uniprot ID: | ITF2_HUMAN |
| Immunogen Region: | 1-210 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human TCF4 (NP_003190.1). |
| Immunogen Sequence: | MHHQQRMAALGTDKELSDLL DFSAMFSPPVSSGKNGPTSL ASGHFTGSNVEDRSSSGSWG NGGHPSPSRNYGDGTPYDHM TSRDLGSHDNLSPPFVNSRI QSKTERGSYSSYGRESNLQG CHQQSLLGGDMDMGNPGTLS PTKPGSQYYQYSSNNPRRRP LHSSAMEVQTKKVRKVPPGL PSSVYAPSASTADYNRDSPG YPSSKPATST |
| Tissue Specificity | Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain. |
| Function | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. |
| Protein Name | Transcription Factor 4 Tcf-4 Class B Basic Helix-Loop-Helix Protein 19 Bhlhb19 Immunoglobulin Transcription Factor 2 Itf-2 Sl3-3 Enhancer Factor 2 Sef-2 |
| Database Links | Reactome: R-HSA-525793 Reactome: R-HSA-9839394 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor 4 antibody Anti-Tcf-4 antibody Anti-Class B Basic Helix-Loop-Helix Protein 19 antibody Anti-Bhlhb19 antibody Anti-Immunoglobulin Transcription Factor 2 antibody Anti-Itf-2 antibody Anti-Sl3-3 Enhancer Factor 2 antibody Anti-Sef-2 antibody Anti-TCF4 antibody Anti-BHLHB19 antibody Anti-ITF2 antibody Anti-SEF2 antibody |
Information sourced from Uniprot.org