• Immunohistochemistry analysis of paraffin-embedded human brain tissue, using E2A Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-TCF3 antibody (321-370 aa) (STJ92806)

SKU:
STJ92806

Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Transcription factor E2-alpha (321-370 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TCF3
Gene ID: 6929
Uniprot ID: TFE2_HUMAN
Immunogen Region: 321-370 aa
Specificity: E2A Polyclonal Antibody detects endogenous levels of E2A protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human E2A at the amino acid range 321-370
Function Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with TCF15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. Isoform E47: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity.
Protein Name Transcription Factor E2-Alpha
Class B Basic Helix-Loop-Helix Protein 21
Bhlhb21
Immunoglobulin Enhancer-Binding Factor E12/E47
Immunoglobulin Transcription Factor 1
Kappa-E2-Binding Factor
Transcription Factor 3
Tcf-3
Transcription Factor Itf-1
Database Links Reactome: R-HSA-525793
Reactome: R-HSA-8939236
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transcription Factor E2-Alpha antibody
Anti-Class B Basic Helix-Loop-Helix Protein 21 antibody
Anti-Bhlhb21 antibody
Anti-Immunoglobulin Enhancer-Binding Factor E12/E47 antibody
Anti-Immunoglobulin Transcription Factor 1 antibody
Anti-Kappa-E2-Binding Factor antibody
Anti-Transcription Factor 3 antibody
Anti-Tcf-3 antibody
Anti-Transcription Factor Itf-1 antibody
Anti-TCF3 antibody
Anti-BHLHB21 antibody
Anti-E2A antibody
Anti-ITF1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance