| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TBXAS1 (355-534) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TBXAS1 |
| Gene ID: |
6916 |
| Uniprot ID: |
THAS_HUMAN |
| Immunogen Region: |
355-534 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 355-534 of human Thromboxane synthase (NP_001052.2). |
| Immunogen Sequence: |
TYLLATNPDCQEKLLREVDV FKEKHMAPEFCSLEEGLPYL DMVIAETLRMYPPAFRFTRE AAQDCEVLGQRIPAGAVLEM AVGALHHDPEHWPSPETFNP ERFTAEARQQHRPFTYLPFG AGPRSCLGVRLGLLEVKLTL LHVLHKFRFQACPETQVPLQ LESKSALGPKNGVYIKIVSR |
| Tissue Specificity | Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. |
| Function | Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE. |
| Protein Name | Thromboxane-A SynthaseTxa SynthaseTxsCytochrome P450 5a1Hydroperoxy Icosatetraenoate Dehydratase |
| Database Links | Reactome: R-HSA-211979Reactome: R-HSA-2162123Reactome: R-HSA-5579032 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Thromboxane-A Synthase antibodyAnti-Txa Synthase antibodyAnti-Txs antibodyAnti-Cytochrome P450 5a1 antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-TBXAS1 antibodyAnti-CYP5 antibodyAnti-CYP5A1 antibodyAnti-TXAS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
