Anti-TBXAS1 antibody (1-100) [S3MR] (STJ11102283)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Thromboxane synthase (1-100) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S3MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TBXAS1 |
| Gene ID | 6916 |
| Uniprot ID | THAS_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MEALGFLKLEVNGPMVTVAL SVALLALLKWYSTSAFSRLE KLGLRHPKPSPFIGNLTFFR QGFWESQMELRKLYGPLCGY YLGRRMFIVISEPDMIKQVL |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Thromboxane synthase (P24557). |
Additional Info
| Tissue Specificity | Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. |
| Function | Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE. |
| Protein Name | Thromboxane-A SynthaseTxa SynthaseTxsCytochrome P450 5a1Hydroperoxy Icosatetraenoate Dehydratase |
| Database Links | Reactome: R-HSA-211979Reactome: R-HSA-2162123Reactome: R-HSA-5579032 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Thromboxane-A Synthase antibodyAnti-Txa Synthase antibodyAnti-Txs antibodyAnti-Cytochrome P450 5a1 antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-TBXAS1 antibodyAnti-CYP5 antibodyAnti-CYP5A1 antibodyAnti-TXAS antibody |
Information sourced from Uniprot.org