| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TBX5 |
| Gene ID: | 6910 |
| Uniprot ID: | TBX5_HUMAN |
| Immunogen Region: | 1-70 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human TBX5 (NP_852259.1). |
| Immunogen Sequence: | MADADEGFGLAHTPLEPDAK DLPCDSKPESALGAPSKSPS SPQAAFTQQGMEGIKVFLHE RELWLKFHEV |
| Post Translational Modifications | Acetylation at Lys-339 by KAT2A and KAT2B promotes nuclear retention. |
| Function | DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter. |
| Protein Name | T-Box Transcription Factor Tbx5T-Box Protein 5 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-5578768Reactome: R-HSA-9733709 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Cytoplasm And The NucleusAcetylation At Lys-339 Promotes Nuclear Retention |
| Alternative Antibody Names | Anti-T-Box Transcription Factor Tbx5 antibodyAnti-T-Box Protein 5 antibodyAnti-TBX5 antibody |
Information sourced from Uniprot.org