| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TBL1XR1 |
| Gene ID: | 79718 |
| Uniprot ID: | TBL1R_HUMAN |
| Immunogen Region: | 120-170 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-170 of human TBL1XR1 (NP_078941.2). |
| Immunogen Sequence: | QQGSAKNGENTANGEENGAH TIANNHTDMMEVDGDVEIPP NKAVVLRGHES |
| Tissue Specificity | Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver. |
| Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. |
| Protein Name | F-Box-Like/Wd Repeat-Containing Protein Tbl1xr1Nuclear Receptor Corepressor/Hdac3 Complex Subunit Tblr1Tbl1-Related Protein 1Transducin Beta-Like 1x-Related Protein 1 |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054Reactome: R-HSA-381340Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-9022537Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9609690Reactome: R-HSA-9707564Reactome: R-HSA-9707616 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-F-Box-Like/Wd Repeat-Containing Protein Tbl1xr1 antibodyAnti-Nuclear Receptor Corepressor/Hdac3 Complex Subunit Tblr1 antibodyAnti-Tbl1-Related Protein 1 antibodyAnti-Transducin Beta-Like 1x-Related Protein 1 antibodyAnti-TBL1XR1 antibodyAnti-IRA1 antibodyAnti-TBLR1 antibody |
Information sourced from Uniprot.org
