| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Tubulin-specific chaperone D (419-469 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TBCD |
| Gene ID: |
6904 |
| Uniprot ID: |
TBCD_HUMAN |
| Immunogen Region: |
419-469 aa |
| Specificity: |
This antibody detects endogenous levels of TBCD at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human TBCD at the amino acid range 419-469 |
| Function | Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis. |
| Protein Name | Tubulin-Specific Chaperone DBeta-Tubulin Cofactor DTfcdSsd-1Tubulin-Folding Cofactor D |
| Database Links | Reactome: R-HSA-389977 |
| Cellular Localisation | Cell JunctionTight JunctionLateral Cell MembraneCytoplasmAdherens JunctionCytoskeletonMicrotubule Organizing CenterCentrosomeLocalized In Cell-Cell Contacts |
| Alternative Antibody Names | Anti-Tubulin-Specific Chaperone D antibodyAnti-Beta-Tubulin Cofactor D antibodyAnti-Tfcd antibodyAnti-Ssd-1 antibodyAnti-Tubulin-Folding Cofactor D antibodyAnti-TBCD antibodyAnti-KIAA0988 antibodyAnti-SSD1 antibodyAnti-TFCD antibodyAnti-PP1096 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
