Anti-TBC1D4 antibody [PT0652R] (STJA0039306)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-Tbc1 Domain Family Member 4 for use in WB, IF, IP and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT0652R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | WB 1:2000-1:10000IF 1:200-1:1000ELISA 1:5000-1:20000IP 1:50-1:200 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TBC1D4 |
| Gene ID | 9882 |
| Uniprot ID | TBCD4_HUMAN |
| Specificity | Endogenous |
Additional Info
| Post Translational Modifications | Phosphorylated by AKT1.insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients. |
| Function | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. |
| Protein Name | Tbc1 Domain Family Member 4Akt Substrate Of 160 KdaAs160 |
| Database Links | Reactome: R-HSA-1445148 |
| Cellular Localisation | CytoplasmIsoform 2 Shows A Cytoplasmic Perinuclear Localization In A Myoblastic Cell Line In Resting And Insulin-Stimulated Cells |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 4 antibodyAnti-Akt Substrate Of 160 Kda antibodyAnti-As160 antibodyAnti-TBC1D4 antibodyAnti-AS160 antibodyAnti-KIAA0603 antibody |
Information sourced from Uniprot.org