| Tissue Specificity | Highly expressed in immune cell types such as B-cells, neutrophils, dendritic cells and monocytes, the expression levels are two-three-fold higher in female cells compared to male cells (at protein level). Expressed at low levels in T-cells and NK cells. |
| Post Translational Modifications | The phosphorylated pLxIS motif constitutes an IRF5-binding motif, leading to recruitment of the transcription factor IRF5 to induce type-I interferons and other cytokines. |
| Function | Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. |
| Protein Name | Tlr Adapter Interacting With Slc15a4 On The Lysosome |
| Database Links | Reactome: R-HSA-9860276 |
| Cellular Localisation | Lysosome MembraneEndosome MembraneNucleusCytoplasmRecruited To Endolysosome Following Interaction With Slc15a4May Colocalize With Tlr7 In The Endosomal Pathway |
| Alternative Antibody Names | Anti-Tlr Adapter Interacting With Slc15a4 On The Lysosome antibodyAnti-TASL antibodyAnti-CXorf21 antibody |
Information sourced from Uniprot.org
