Anti-TASL antibody (96-196) (STJ11103338)

Name: Anti-TASL antibody (96-196) (STJ11103338)
SKU: STJ11103338
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11103338

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Short Description	Rabbit polyclonal TASL (96-196) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ELISA
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	TASL
Gene ID	80231
Uniprot ID	TASL_HUMAN
Immunogen Region	96-196
Immunogen Sequence	NLAAVEICRDASRETYLVPS SCKSICKNYNDLQIAGGQVM AINSVTTDFPSESSFEYGPL LKSSEIPLPMEDSISTQPSD FPQKPIQRYSSYWRITSIKE K
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 96-196 of human TASL (NP_079435.1).

Tissue Specificity	Highly expressed in immune cell types such as B-cells, neutrophils, dendritic cells and monocytes, the expression levels are two-three-fold higher in female cells compared to male cells (at protein level). Expressed at low levels in T-cells and NK cells.
Post Translational Modifications	The phosphorylated pLxIS motif constitutes an IRF5-binding motif, leading to recruitment of the transcription factor IRF5 to induce type-I interferons and other cytokines.
Function	Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes.
Protein Name	Tlr Adapter Interacting With Slc15a4 On The Lysosome
Database Links	Reactome: R-HSA-9860276
Cellular Localisation	Lysosome Membrane Endosome Membrane Nucleus Cytoplasm Recruited To Endolysosome Following Interaction With Slc15a4 May Colocalize With Tlr7 In The Endosomal Pathway
Alternative Antibody Names	Anti-Tlr Adapter Interacting With Slc15a4 On The Lysosome antibody Anti-TASL antibody Anti-CXorf21 antibody

Information sourced from Uniprot.org