Anti-TARBP1 antibody (1322-1621) (STJ11103358)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TARBP1 (1322-1621) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TARBP1 |
| Gene ID | 6894 |
| Uniprot ID | TARB1_HUMAN |
| Immunogen Region | 1322-1621 |
| Immunogen Sequence | QVESMHGAGNAKKNWQRIQE HFFFATFHPLKDYCLETIFY ILPRLSGLIEDEWITIDKFT RFTDVPLAAGFQWYLSQTQL SKLKPGDWSQQDIGTNLVEA DNQAEWTDVQKKIIPWNSRV SDLDLELLFQDRAARLGKSI SRLIVVASLIDKPTNLGGLC RTCEVFGASVLVVGSLQCIS DKQFQHLSVSAEQWLPLVEV KPPQLIDYLQQKKTEGYTII GVEQTAKSLDLTQYCFPEK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1322-1621 of human TARBP1 (NP_005637.3). |
Additional Info
| Function | S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs. (Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. |
| Protein Name | TrnaGuanosine(18-2'-O-Methyltransferase Tarbp1Tar Rna-Binding Protein 1Tar Rna-Binding Protein Of 185 KdaTrp-185 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Trna antibodyAnti-Guanosine(18-2'-O-Methyltransferase Tarbp1 antibodyAnti-Tar Rna-Binding Protein 1 antibodyAnti-Tar Rna-Binding Protein Of 185 Kda antibodyAnti-Trp-185 antibodyAnti-TARBP1 antibodyAnti-TRM3 antibodyAnti-TRP185 antibody |
Information sourced from Uniprot.org