Anti-TAOK2 antibody (STJ191990)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Serine/threonine-protein kinase TAO2 for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TAOK2 |
| Gene ID | 9344 |
| Uniprot ID | TAOK2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | TAOK2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Isoforms 1 and 2 are autophosphorylated. C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity. Autophosphorylated. Phosphorylated by ATM. Isoform 2: Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis. |
| Function | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. |
| Protein Name | Serine/Threonine-Protein Kinase Tao2Kinase From Chicken Homolog CHkfc-CProstate-Derived Sterile 20-Like Kinase 1Psk-1Psk1Prostate-Derived Ste20-Like Kinase 1Thousand And One Amino Acid Protein Kinase 2 |
| Database Links | |
| Cellular Localisation | Cytoplasmic Vesicle MembraneMulti-Pass Membrane ProteinCytoplasmCytoskeletonNucleusCatalytically Active Full-Length Phosphorylated Isoform 1 Localizes To Microtubules In The Cytoplasm Predominantly On Microtubule Cables Positioned Around The NucleusA C-Terminally Truncated Form Of Isoform 1 Is Present In The NucleusIsoform 2 And Kinase-DefectiveAs Well As Full-Length Isoform 1 Are Excluded From The NucleusIsoform 2: Cell ProjectionDendriteIn DendritesColocalizes With Pcdh8 |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tao2 antibodyAnti-Kinase From Chicken Homolog C antibodyAnti-Hkfc-C antibodyAnti-Prostate-Derived Sterile 20-Like Kinase 1 antibodyAnti-Psk-1 antibodyAnti-Psk1 antibodyAnti-Prostate-Derived Ste20-Like Kinase 1 antibodyAnti-Thousand And One Amino Acid Protein Kinase 2 antibodyAnti-TAOK2 antibodyAnti-KIAA0881 antibodyAnti-MAP3K17 antibodyAnti-PSK antibodyAnti-PSK1 antibodyAnti-UNQ2971 antibodyAnti-PRO7431 antibody |
Information sourced from Uniprot.org