| Post Translational Modifications | Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated.this leads to degradation. Deubiquitinated by USP25.leading to stabilization. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer. |
| Function | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity. |
| Protein Name | Poly Adp-Ribose Polymerase Tankyrase-2Adp-Ribosyltransferase Diphtheria Toxin-Like 6Artd6Poly Adp-Ribose Polymerase 5bProtein Poly-Adp-Ribosyltransferase Tankyrase-2Tnks-2Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2Tankyrase IiTankyrase-2Tank2Tankyrase-Like ProteinTankyrase-Related Protein |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4641257Reactome: R-HSA-5545619Reactome: R-HSA-5689880Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinNucleusChromosomeTelomereAssociated With The Golgi And With Juxtanuclear Slc2a4/Glut4-VesiclesAlso Found Around The Pericentriolar Matrix Of Mitotic CentromeresDuring InterphaseA Small Fraction Of Tnks2 Is Found In The NucleusAssociated With Trf1 |
| Alternative Antibody Names | Anti-Poly Adp-Ribose Polymerase Tankyrase-2 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 6 antibodyAnti-Artd6 antibodyAnti-Poly Adp-Ribose Polymerase 5b antibodyAnti-Protein Poly-Adp-Ribosyltransferase Tankyrase-2 antibodyAnti-Tnks-2 antibodyAnti-Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2 antibodyAnti-Tankyrase Ii antibodyAnti-Tankyrase-2 antibodyAnti-Tank2 antibodyAnti-Tankyrase-Like Protein antibodyAnti-Tankyrase-Related Protein antibodyAnti-TNKS2 antibodyAnti-PARP5B antibodyAnti-TANK2 antibodyAnti-TNKL antibody |
Information sourced from Uniprot.org
