Anti-TANK antibody (1-119) (STJ28846)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TANK (1-119) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TANK |
| Gene ID | 10010 |
| Uniprot ID | TANK_HUMAN |
| Immunogen Region | 1-119 |
| Immunogen Sequence | MDKNIGEQLNKAYEAFRQAC MDRDSAVKELQQKTENYEQR IREQQEQLSLQQTIIDKLKS QLLLVNSTQDNNYGCVPLLE DSETRKNNLTLDQPQDKVIS GIAREKLPKVDIASAESSI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-119 of human TANK (NP_597841.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated by IKBKE. (Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C. This cleavage allows the virus to disrupt the TANK-TBK1-IKKepsilon-IRF3 complex, thereby inhibiting the induction of the IFN-beta signal pathway. (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways. |
| Function | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. |
| Protein Name | Traf Family Member-Associated Nf-Kappa-B ActivatorTraf-Interacting ProteinI-Traf |
| Database Links | Reactome: R-HSA-9013973Reactome: R-HSA-933541Reactome: R-HSA-936964Reactome: R-HSA-9824878Reactome: R-HSA-9828211 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Traf Family Member-Associated Nf-Kappa-B Activator antibodyAnti-Traf-Interacting Protein antibodyAnti-I-Traf antibodyAnti-TANK antibodyAnti-ITRAF antibodyAnti-TRAF2 antibody |
Information sourced from Uniprot.org