Anti-TADA2A antibody (1-443) (STJ110755)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TADA2A (1-443) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TADA2A |
| Gene ID | 6871 |
| Uniprot ID | TAD2A_HUMAN |
| Immunogen Region | 1-443 |
| Immunogen Sequence | MDRLGSFSNDPSDKPPCRGC SSYLMEPYIKCAECGPPPFF LCLQCFTRGFEYKKHQSDHT YEIMTSDFPVLDPSWTAQEE MALLEAVMDCGFGNWQDVAN QMCTKTKEECEKHYMKHFIN NPLFASTLLNLKQAEEAKTA DTAIPFHSTDDPPRPTFDSL LSRDMAGYMPARADFIEEFD NYAEWDLRDIDFVEDDSDIL HALKMAVVDIYHSRLKERQR RKKIIRDHGLINLRKFQLM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-443 of human TADA2A (NP_001159577.2). |
Additional Info
| Tissue Specificity | Expressed in all tissues, but most abundantly in testis. |
| Function | Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. |
| Protein Name | Transcriptional Adapter 2-AlphaTranscriptional Adapter 2-LikeAda2-Like Protein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Transcriptional Adapter 2-Alpha antibodyAnti-Transcriptional Adapter 2-Like antibodyAnti-Ada2-Like Protein antibodyAnti-TADA2A antibodyAnti-TADA2L antibodyAnti-KL04P antibody |
Information sourced from Uniprot.org