Anti-TACC3 antibody [R05-8B1] (STJA0035797)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human TACC3
General Information
| Short Description | Rabbit monoclonal anti-TACC3 for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-8B1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TACC3 |
| Gene ID | 10460 |
| Uniprot ID | TACC3_HUMAN |
| Immunogen | A synthesized peptide derived from human TACC3 |
Additional Info
| Function | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell growth and differentiation. May contribute to cancer. |
| Protein Name | Transforming Acidic Coiled-Coil-Containing Protein 3Eric-1 |
| Database Links | Reactome: R-HSA-9013507Reactome: R-HSA-9604323 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleSpindle PoleIn Complex With Ckap5 Localized To Microtubule Plus-Ends In Mitosis And InterphaseIn Complex With Ckap5 And Clathrin Localized To Inter-Microtubule Bridges In Mitotic Spindles |
| Alternative Antibody Names | Anti-Transforming Acidic Coiled-Coil-Containing Protein 3 antibodyAnti-Eric-1 antibodyAnti-TACC3 antibodyAnti-ERIC1 antibody |
Information sourced from Uniprot.org